This is an update to the original EO notice dated March 21, 2018. April 27, 2018 . Increases in the availability of naloxone, Good Samaritan laws, and education for the public regarding the safety and utility of naloxone can reduce the number of overdoses. ORTHN interventions were implemented in over 15 services across New South Wales, Australia. naloxone is a topic covered in the Davis's Drug Guide.. To view the entire topic, please sign in or purchase a subscription.. a buprenorphine/naloxone combination product, ... An extensive research was done in the field of nursing and addiction treatment and recent evidence based practice information was incorporated into the publication. Naloxone is the antagonist of choice to reverse the respiratory and central nervous system depression caused by opioid overdose. Between 1996, when naloxone was first made available to laypersons, and June of 2014, more than 150,000 naloxone kits were distributed, and 26,463 overdoses were reversed. The final dr aft of the guideline was reviewed by two addiction expert nurses, as well as experts from SAMHSA, FDA and NIDA. Educational intervention should include signs of opioid overdose, proper administration of the reversal agent, naloxone, and essential overdose after-care (American Society of Addiction Medicine [ASAM], 2016). Health care providers who administer naloxone in the course of their work will have professional standards of practice that may not be covered in this manual. However, naloxone has only a 30-minute half-life in some patients, so it may have to be readministered. Look up information on diseases, tests, and procedures; then consult the database with 5,000+ drugs or refer to 65,000+ dictionary terms. DESIGN AND METHODS: Service providers, consumers and regulators collaboratively designed a THN brief intervention (ORTHN, Overdose Response with Take-Home Naloxone) involving client education and supply of naloxone in pre-filled syringes, delivered by nursing, allied health and NSP workers. Deborah S. Finnell is a professor and Christine L. Savage is adjunct professor, both at Johns Hopkins School of Nursing in Baltimore, Maryland. Naloxone Administration When providing patients with naloxone—which, depending on state laws, could be accomplished without a prescription or through collaborative practice agreements with physicians or standing orders—pharmacists should make a point to demonstrate how to administer the product. Although its method of action isn't completely understood, evidence suggests that naloxone antagonizes opioid effects by competing for the mu, kappa, and sigma opioid receptor sites in the central nervous system. 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